The Commission of India was established in Georgetown in May 1965. The Commission was made into a full-fledged High Commission of India in 1968. The Indian Cultural Centre was set up in 1972.

The relationship between India and Guyana ever since the independence of Guyana in May 1966 has been close and cordial with a high degree of understanding. The warmth in the relation remains unaffected with changes in governments either in India or in Guyana. Late Shrimati Indira Gandhi, the then Prime Minister of India, visited Guyana in 1968, late Dr. Shankar Dayal Sharma, the then Vice President of India visited Guyana in 1988 and Shri Bhairon Singh Shekhawat, the then Vice President of India came on a state visit to Guyana in 2006.

India and Guyana all along view each other as strategic partners and cooperate in the international arena where there exists a clear convergence of views on issues of mutual interest. Guyana, however, closed down its Mission in India in 1990 due to economic reasons, but reopened it in 2004. President Mr. Bharrat Jagdeo made a state visit to India in 2003 and in 2004; President Jagdeo was the Chief Guest at the 2nd Pravasi Bharatiya Divas celebrations and received the Pravasi Bharatiya Samman Award.